2015, Article / Letter to editor (JMIR Research Protocols, vol. 4, iss. 4, (2015))Background: Every day rheumatoid arthritis (RA) patients make many decisions about managing their disease. An online, computer-tailored, self-management program can support this decision making, but development of such a program requires the active participation of patients. Objective: To develop an online, computer-tailored, self-management program integrated with the nursing care, as nurses have an important role in supporting self-management behavior. Methods: The intervention mapping framework was used to develop the program. Development was a multistep process: (1) needs assessment; (2) developing program and change objectives in a matrix; (3) selecting theory-based intervention methods and practical application strategies; (4) producing program components; (5) planning and adoption, implementation, and sustainability; and (6) planning for evaluation. Results: After conducting the needs assessment (step 1), nine health-related problems were identified: (1) balancing rest and activity, (2) setting boundaries, (3) asking for help and support, (4) use of medicines, (5) communicating with health professionals, (6) use of assistive devices, (7) performing physical exercises, (8) coping with worries, and (9) coping with RA. After defining performance and change objectives (step 2), we identified a number of methods which could be used to achieve them (step 3), such as provision of general information about health-related behavior, self-monitoring of behavior, persuasive communication, modeling, and self-persuasion and tailoring. We described and operationalized these methods in texts, videos, exercises, and a medication intake schedule. The resulting program (step 4) consisted of an introduction module and nine modules dealing with health-related problems. The content of these modules is tailored to the user's self-efficacy, and patients can use the online program as often as they want, working through a module or modules at their own speed. After implementation (step 5), the program will be evaluated in a two-center pilot trial involving 200 RA patients. Log-in data and qualitative interviews will used for a process evaluation. Conclusions: The intervention mapping framework was used to guide development of an online computer-tailored self-management program via a process which could serve as a model for the development of other interventions. A pilot randomized controlled trial (RCT) will provide insight into the important outcome measures in preparation for a larger RCT. The process evaluation will provide insight into how RA patients use the program and the attrition rate.
2012, Article / Letter to editor (FEMS Microbiol Letters, vol. 335, iss. 2, (2012), pp. 104-112)To increase knowledge on haem biosynthesis in filamentous fungi like Aspergillus niger, pathway-specific gene expression in response to haem and haem intermediates was analysed. This analysis showed that iron, 5-aminolevulinic acid (ALA) and possibly haem control haem biosynthesis mostly via modulating expression of hemA [coding for 5-aminolevulinic acid synthase (ALAS)]. A hemA deletion mutant (?hemA) was constructed, which showed conditional lethality. Growth of ?hemA was supported on standard nitrate-containing media with ALA, but not by hemin. Growth of ?hemA could be sustained in the presence of hemin in combination with ammonium instead of nitrate as N-source. Our results suggest that a branch-off within the haem biosynthesis pathway required for sirohaem synthesis is responsible for lack of growth of ?hemA in media containing nitrate as sole N-source, because of the requirement of sirohaem for nitrate assimilation, as a cofactor of nitrite reductase. In contrast to the situation in Saccharomyces cerevisiae, cysteine, but not methionine, was found to further improve growth of ?hemA. These results demonstrate that A. niger can use exogenous hemin for its cellular processes. They also illustrate important differences in regulation of haem biosynthesis and in the role of haem and sirohaem in A. niger compared to S. cerevisiae.
2011, Article in monograph or in proceedings (EEVC)The objective of an energy management strategy for fuel cell hybrid propulsion systems is to minimize the fuel needed to provide the required power demand. This minimization is defined as an optimization problem. Methods such as dynamic programming numerically solve this optimization problem. Strategies such as the equivalent consumption minimization strategy derive an analytical solution based on low-order models that approximate fuel cell stack and battery behavior. This paper presents an analytical solution based on models of the fuel cell system and battery close to physics. Apart from an analytical solution, this solution provides a fundamental understanding of the energy management problem. Because the solution is analytic and does not need a priori knowledge, the computation time is limited, and real-time implementation is possible. The solution presented is validated against existing optimizing energy management strategies in both simulations and experiments. For simulations, a midsize distribution truck is chosen. Experiments are carried out on a 10-kW scale test facility that comprises a fuel cell system, a battery, a motor with load, and an electronic load. In both simulations and measurements, the solution presented in this paper performs best compared to the equivalent consumption minimization strategy and a range-extender strategy, although the differences are within 3%. In the simulations, the solution presented approaches a minimum in fuel consumption, derived offline using dynamic programming, within 1%.
2012, Article / Letter to editor (IEEE Transactions on Vehicular Technology, vol. 61, iss. 5, (2012), pp. 1986-1998)The objective of an energy management strategy for fuel cell hybrid propulsion systems is to minimize the fuel needed to provide the required power demand. This minimization is defined as an optimization problem. Methods such as dynamic programming numerically solve this optimization problem. Strategies such as the equivalent consumption minimization strategy derive an analytical solution based on low-order models that approximate fuel cell stack and battery behavior. This paper presents an analytical solution based on models of the fuel cell system and battery close to physics. Apart from an analytical solution, this solution provides a fundamental understanding of the energy management problem. Because the solution is analytic and does not need a priori knowledge, the computation time is limited, and real-time implementation is possible. The solution presented is validated against existing optimizing energy management strategies in both simulations and experiments. For simulations, a midsize distribution truck is chosen. Experiments are carried out on a 10-kW scale test facility that comprises a fuel cell system, a battery, a motor with load, and an electronic load. In both simulations and measurements, the solution presented in this paper performs best compared to the equivalent consumption minimization strategy and a range-extender strategy, although the differences are within 3%. In the simulations, the solution presented approaches a minimum in fuel consumption, derived offline using dynamic programming, within 1%.[
2017, Article in monograph or in proceedings (2nd International Workshop on Extraction and Processing of Rich Semantics from Medical Texts)We present a multilingual, open source system for cancer forum thread analysis, equipped with a biomedical entity tagger and a module for textual summarization. This system allows users to investi- gate textual co-occurrences of biomedical entities in forum posts, and to browse through summaries of long discussions. It is applied to a number of online cancer patient fora, including a gastro-intestinal cancer forum and a breast cancer forum. We propose that the system can serve as an extra source of information for medical hypothesis formulation, and as a facility for boosting patient empowerment.
2017, Article / Letter to editor (vol. 5, iss. Vol. 5, nr. 1, (2017), pp. 26-42)In this article, we present a method for analyzing the communication of people who exchange dynamic and complex information to come to a shared understanding of situations and of the actions planned and monitored by one party, but executed remotely by another. To examine this situation, we analyzed dispatchers working in police dispatch center in a large city in the Netherlands and their communication behavior in three different settings. The results of our analyses answer the question of how collaborative parties should assess an emergency situation in order to decide how to handle the incident in accordance with the procedures. Our results indicate which information must be communicated in order to deal with the current problem during the course of an incident. We will also demonstrate the proposed way of analyzing the communication used here is needed to understand how information is collaboratively handled in complex tasks.
2011, Article / Letter to editor (Nieuwsbrief Nederlandse Vereniging voor Bio-Ethiek, vol. 18, iss. 2, (2011), pp. 20-21)Een ruim decennium onderweg in de 21 eeuw wordt duidelijk dat informatie steeds belangrijker en toegankelijker wordt in onze samenleving. Gegevens die vroeger niet, of slechts via ingewikkelde bureaucratische wegen verkrijgbaar waren, zijn nu vaak gratis in te zien. Ook over de gezondheidzorg zijn steeds meer data publiekelijk beschikbaar. Moesten we het niet eens zo lang geleden nog doen met het Elseviers lijstje van beste ziekenhuizen, nu kunnen we allerlei prestatie-indicatoren, patiëntenoordelen en wachtlijstcijfers gewoon zelf opzoeken. Lang niet iedereen maakt hier gebruik van natuurlijk. We mogen ervan uitgaan dat vooral onder hoger opgeleiden deze beschikbaarheid van informatie leidt tot kritischer consumenten patiëntschap.
2022, Article / Letter to editor (International Journal of Sports Science & Coaching, (2022))This study examined the influence of both anthropometric and physical performance determinants on the likelihood to be selected to progress through a talent identification and development programme in young tennis. Data were collected in 538 young tennis players (323 males and 215 females) from 6 age categories (U8-U13). A principal component analysis was used to generate one anthropometric determinant (based on body height, body weight and maturity offset) and four physical performance determinants: speed and agility (based on 5 m sprint, 20 m sprint and 505 change of direction test); jumping power (based on standing broad jump and standing broad jump in series); motor coordination (based on balancing backwards and jumping sideways) and tennis ball control (based on a throw and catch test and hold tennis ball up test). For all determinants, tertiles were generated for every age category and both sexes separately. Univariate binary logistic regressions were performed to examine the influence of each determinant on the chances to be selected to progress in the talent identification and development programme. Significant odds ratios were found for all included anthropometric and physical performance determinants (p < 0.05), ranging from 0.26 to 7.50 in the male young tennis players and from 0.18 to 6.87 in the female young tennis players. The included determinants influenced selection chances mostly in the early age categories (U8-U10) as opposed to the later age categories (U11-U13). Future research should examine the influence of additional determinants (such as tennis (match-play) performance) on the selection chances to progress through a talent identification and development programme.
2016, Article / Letter to editor (International Journal of Sports Medicine, vol. 37, iss. 7, (2016), pp. 531-538)The aim of the present study was to identify anthropometric, physical, coordinative and ice-skating specific characteristics that discriminate young elite ice skaters from non-elite skaters and their non-skating peers. 32 skaters aged 9-12 years old (11 elites and 21 non-elites) voluntarily participated in the study. They were submitted to 5 anthropometric, 7 physical, 3 coordination and 5 ice-skating specific tests. Reference values of a representative healthy non-skating sample were taken from the Flemish Sports Compass dataset. Figure skaters appeared to be predominantly average mature (93.8%), were lighter and leaner than the reference sample, and demonstrated better physical characteristics and motor coordination. There was no difference between the elite and non-elite group regarding maturity status and anthropometric or physical parameters. Still, elite skaters scored better than non-elites on the coordination tests jumping sideways and tended to do so on the moving sideways test. Profiles of figure skaters differ clearly from a reference population, while non-sport-specific motor coordination tests allow discrimination between elite and non-elite skaters. The relevance of these findings with respect to talent detection and identification in young ice skaters are discussed.
2017, External research report Academische opleidingsscholen combineren inmiddels al tien jaar op succesvolle wijze de lerarenopleiding met praktijkonderzoek. Wat is hun geheim? Gedurende tien jaar is binnen academische opleidingsscholen (AOS) gewerkt aan de structuur en cultuur die nodig is om onderzoek in de school uit te voeren. Daarmee zijn zij voorlopers in de ontwikkeling naar meer praktijkonderzoek in de school. Zij zijn in die tien jaar unieke ervaringsdeskundigen geworden. Er zijn weinig scholen die zoveel onderzoekservaring hebben opgedaan en gewerkt hebben aan een onderzoekende cultuur. Per 1 januari 2017 is de subsidie voor de academische kop officieel gestopt, een mooi moment om terug te kijken welke lessen we kunnen leren over praktijkonderzoek in de school. Het delen van de ervaringen van deze scholen kan andere scholen die meer onderzoekend willen werken inspireren en richting geven.
2009, Article / Letter to editor (Opleiding en Ontwikkeling, (2009))In deze reportage de mogelijkheden van software ter ondersteuning van talentmanagement besproken, waarbij specifiek wordt gekeken naar de toepassingsmogelijkheden voor HRD’ers.
2017, Article in monograph or in proceedings (In MATEC Web of Conferences 127, 01006 (2017))In this paper we explain why Axiomatic design has not been applied in large system of systems information technology architectures in health care organizations in the Netherlands. We have found in extensive case studies of IT systems that the Independence axiom could not be found in the existing Information systems. This causes great concern for the adaptability of systems. Although best practices in system engineering advice decoupling of system functionality, findings show that the Independence Axiom has not been applied to functional requirements. A number of difficulties was exposed to the researcher and IT architects, when they tried to identify and to demarcate functional requirements in existing systems. In IT systems a distinction is made between business and system functions and software engineers emphasize decoupling of system functions. That has resulted in a strong coupling of business information and technical application logic. This means Conceptual dependencies are often at the heart of the difficulties. Decoupling these dependencies in applications seems a candidate for ordering requirements in a way that keeps the functional requirements independent from each other. Conceptual independence signifies a complete decoupling of the concepts and relations of the Business domain from the technical functionality. The paper describes the difficulties when applying the Independence Axiom in the Information systems domain and argues that a combination of Conceptual independence and Axiomatic design is achievable. The authors adapt the Design matrix with Conceptual independence. We conclude that applying Conceptual independence is crucial when constructing IT systems based on Axiomatic design.
Components in Home care institute.
Components in Home care institute.
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. Descriptions of DPs.
. Descriptions of DPs.
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2015, Article / Letter to editor (Elsevier, vol. 34, (2015), pp. 263-268)Abstract This paper applies and discusses the principles of Axiomatic Design for changing IT architecture in health care. It presents three case studies positioned in the field of Enterprise architecture that explore how IT architects, as professionals, manage change and re-design the structure of the IT systems in line with strategic goals. The research approach was to use a light modelling tool, Ampersand, for modelling the Enterprise architecture. Two types of models stand out: Type 1 Strategic IT models in which higher strategic goals are related to requirements for applications and Type 2 Technical management of systems models in which technical risks and risk of system failure in the current IT infrastructure were modelled. To bridge the views of different IT experts in the organization this work uses the customer domain, the functional domain and the physical domain from Axiomatic Design in an extended example in the paper. The V Model is used to bridge the models, and then it is extended with Axiomatic Design principles.
Example of model of type 1 Strategic IT
Example of model of type 1 Strategic IT
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. Context in different case studies.
. Context in different case studies.
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V Model for overview of IT Architecture.
V Model for overview of IT Architecture.
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2015, Article in monograph or in proceedings (Procedia CIRP, pp. 262-268)This paper applies and discusses the principles of Axiomatic Design for changing IT architecture in health care. It presents three case studies positioned in the field of Enterprise architecture that explore how IT architects, as professionals, manage change and re-design the structure of the IT systems in line with strategic goals. The research approach was to use a light modelling tool, Ampersand, for modelling the Enterprise architecture. Two types of models stand out: Type 1 Strategic IT models in which higher strategic goals are related to requirements for applications and Type 2 Technical management of systems models in which technical risks and risk of system failure in the current IT infrastructure were modelled. To bridge the views of different IT experts in the organization this work uses the customer domain, the functional domain and the physical domain from Axiomatic Design in an extended example in the paper. The V Model is used to bridge the models, and then it is extended with Axiomatic Design principles.
2019, Article in monograph or in proceedings (2019 International Conference on Quality, Reliability, Risk, Maintenance, and Safety Engineering (QR2MSE), pp. 631-637)
2011, Book (monograph) Het bevorderen van duurzame arbeidsparticipatie is een kerntaak voor paramedici en arboprofessionals. In sociaal opzicht is arbeidsparticipatie belangrijk omdat het bijdraagt aan zelfstandigheid en zelfrespect. Maar niet iedereen kan een baan vinden of houden. Bovendien zullen door de stijgende pensioenleeftijd meer werknemers te kampen krijgen met arbeidsbeperkingen. Hoe kunt u als paramedicus of arboprofessional uw cliënten ondersteunen in het arbeidsparticipatieproces? Het antwoord op deze vraag vindt u in de tweede editie van Arbeid & Gezondheid. De geactualiseerde denkmodellen en onderwerpen in dit handboek dienen als handvatten voor professionals om de arbeidsparticipatie van hun cliënten te optimaliseren. Daarbij is kennis vanuit verschillende disciplines noodzakelijk. In de eerste editie lag de nadruk op interventie (preventie, behandeling en reïntegratie). Deze uitgebreide herziening bespreekt de rol van professionals in drie praktische contexten: (meer) aan het werk, aan het werk (blijven) en weer aan het werk. Daarvoor wordt in deel 1 het theoretische kader aangeboden. Deel 2 gaat vervolgens in op de praktische kant en geeft onder andere talloze tips, voorbeelden en nuttige adressen.
2010, Article / Letter to editor (Bij de les: magazine voor leerlingbegeleiding en schooldecanaat, vol. 6, iss. 2, (2010), pp. 22)Studiekeuze123.nl is één van de sites waarop studenten en scholieren opleidingen in het hoger onderwijs kunnen vergelijken. Ook hier vinden er ze gegevens over de arbeidsmarkt. Maar hoe werkt Studiekeuze123?
2012, Part of book or chapter of book (, pp. 190-199)Voor steeds meer zorgprocessen komen slimme mogelijkheden voor optimalisaties, door de toepassing van ICT. In dit artikel introduceren we een architectuurbeschrijving van zorgprocessen, die geschikt is om: - ICT innovaties in de gezondheidszorg te positioneren - Samenwerking tussen zorgprofessionals te optimaliseren - Implementatieplannen realiseren
2016, Article / Letter to editor (Family Practice, vol. 33, iss. 4, (2016), pp. 354-359)Some gynaecological and pregnancy-associated conditions are more common in abused women than in non-abused women, but this has not been examined in family practice. We aimed to investigate intimate partner violence (IPV) prevalence in family practice and to investigate whether gynaecological and pregnancy-associated conditions are more common in abused women than in non-abused women. We conducted a cross-sectional waiting room survey in 12 family practices in the Netherlands in 2012. Women were eligible if they were of 18 years or older. Questionnaires measured IPV and gynaecological and pregnancy-associated conditions. Chi-square tests were used to assess the differences in gynaecological and pregnancy-associated conditions between abused women and non-abused women. The response rate was 86% (262 of 306 women). The past-year prevalence of IPV in women who had had an intimate relationship in the past year and were not accompanied by their partner was 8.7% (n = 195). Lifetime prevalence of women who had ever had an intimate relationship, but not in the past year, was 17.6% (n = 51). Sexually transmitted infections (STIs) [odds ratio (OR) = 4.6, 95% confidence interval [CI] = 1.7-12.5, n = 240], menstrual disorders (OR = 3.7, 95% CI = 1.2-11.2, n = 143), sexual problems (OR = 3.3, 95% CI = 1.2-9.3, n = 229), miscarriages (OR = 2.5, 95% CI = 1.062-5.8, n = 202) and induced abortions (OR = 2.7, 95% CI = 1.028-7.3, n = 202) were significantly more common in abused women than in non-abused women. Family physicians should ask about IPV when women present with STIs, menstrual disorders, sexual problems, miscarriages or induced abortions. To improve the recognition of IPV, future research needs to investigate whether a combination of symptoms offers improved prediction of IPV.
2014, Article / Letter to editor (The Review of International Comparative Management, vol. 15, iss. 2, (2014), pp. 154-173)Recent efforts of the European Union to integrate new member states such as Romania expand to the social economy sector as well. Works by Hoogendoorn et al. (2010) and Kerlin (2010) regard Europe as accommodating two schools of thought related to social entrepreneurship: EMES and the UK - social enterprise. Both views place great emphasis on social enterprise as the main indicator of the social entrepreneurial phenomena for the European continent.
2015, Article in monograph or in proceedings (Proceedings of the 23rd International Conference on Computers in Education)Ark of Inquiry is a learning platform that uses a computer-based inquiry learning approach to raise youth awareness to Responsible Research and Innovation (RRI). It is developed in the context of a large-scale European project (http://www.arkofinquiry.eu) and provides young European citizens (7–18-year-olds) with a pool of engaging inquiry activities. Computer-based inquiry learning has been found effective in many studies and is recommended for science education by several countries all over the world. Several EU policy documents, however, have emphasized the need to increase society’s active involvement in knowledge creation and scientific discussions. Therefore, combining computer-based inquiry learning with the ideas of RRI is required. RRI is a key term in the current policy of the European Commission in the field of science education and in linking science with other domains. RRI is a transparent, interactive process by which societal actors and innovators become mutually responsive to each other with a view on the acceptability, sustainability and societal desirability of the innovation process. In the Ark of Inquiry project, we have developed a pedagogy that helps to link RRI to computer-based inquiry learning. In the current theoretical paper, we introduce this approach and explain how this has been implemented in the Ark of Inquiry project.
2012, Article / Letter to editor (The Practice of Enterprise Modeling, vol. 2012, iss. 134, (2012), pp. 16-30)In this paper we explore the subject of question asking as an inherent driver of enterprise modelling sessions, within the narrower context of the ‘dialogue game’ approach to collaborative modelling. We explain the context, but mostly report on matters directly concerning question asking and answer pre-structuring as a central issue in an ongoing effort aiming for the practice-oriented development of a series of dialogue games for collaborative modelling. We believe that our findings can be relevant and helpful to anyone concerned with planning, executing or facilitating collaborative modelling sessions, in particular when involving stakeholders untrained in systems thinking and modelling.