2012, Dissertation Patiënten met RSI hebben niet alleen problemen in de aangedane arm. Ook in de arm zonder klachten zijn spierdoorbloeding, zuurstofopname en vaatfunctie sterk verminderd. Dat concludeert promovendus Jaap Brunnekreef. Verder blijkt dat de spierkarakteristieken van patiënten met RSI-klachten anders zijn dan van gezonde vrijwilligers. Zo kenmerkt het spierweefsel van RSI-patiënten zich door een snellere vermoeidheid. De behandeling van RSI moet hierdoor breder van opzet zijn dan alleen het lokaal behandelen van de klachten, stelt Brunnekreef.
2011, Article / Letter to editor (Journal Orthopaedic Sports and Physical Therapy, vol. 42, iss. 4, (2011), pp. 371-378)To investigate whether oxygen consumption and blood flow at rest and after exercise are lower in the affected arm of patients with repetitive strain injury (RSI) compared to controls, and lower in the healthy nonaffected forearm within patients with unilateral RSI. RSI is considered an upper extremity overuse injury. Despite the local presentation of complaints, RSI may be represented by systemic adaptations. Insight into the pathophysiology of RSI is important to better understand the development of RSI complaints and to develop effective treatment and prevention strategies. Twenty patients with unilateral RSI and 20 gender-matched control subjects participated in this study. Forearm muscle blood flow and oxygen consumption were measured using near-infrared spectroscopy at baseline and immediately after isometric handgrip exercises at 10%, 20%, and 40% of the individual maximal voluntary contraction. Unilateral RSI resulted in a lower oxygen consumption and blood flow in the affected forearm at baseline and lower oxygen consumption after incremental handgrip exercises compared to controls (P<.05). In addition, exercise-induced blood flow and oxygen consumption in the nonaffected forearm in patients with RSI were similarly reduced. Blood flow and oxygen consumption after exercise are similarly attenuated in the affected and nonaffected arms of patients with unilateral RSI. Our findings suggest that, despite the unilateral character in clinical symptoms, RSI demonstrates systemic adaptations in forearm blood flow and oxygen consumption at rest and after exercise.