Browsing by Author "Christensen, R."

Now showing items 1-2 of 2

A consensus-based framework for conducting and reporting osteoarthritis phenotype research.
Spil, W.E. van ; Bierma-Zeinstra, S.M.A. ; Deveza, L.A. ; Arden, N.K. ; Bay-Jensen, A.C. ; Kraus, V.B. ; Carlesso, L. ; Christensen, R. ; Esch, M. van der ; Kent, P. ; Knoop, J. ; Ladel, C. ; Little, C.B. ; Loeser, R.F. ; Losina, E. ; Mills, K. ; Mobasheri, A. ; Nelson, A.E. ; Neogi, T. ; Peat, G.M. ; Rat, A.C. ; Steultjens, M. ; Thomas, M.J. ; Valdes, A.M. ; Hunter, D.J. et al. sine al.
2020, Article / Letter to editor (Arthritis Research & Therapy, vol. 22, iss. 1, (2020), pp. 54)BACKGROUND: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research. METHODS: A panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies. RESULTS: Four Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided. CONCLUSIONS: This study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients.
Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol.
Holden, M.A. ; Burke, D.L. ; Runhaar, J. ; Windt, D. van Der ; Riley, R.D. ; Dziedzic, K. ; Legha, A. ; Evans, A.L. ; Abbott, J.H. ; Baker, K. ; Brown, J. ; Bennell, K.L. ; Bossen, D. ; Brosseau, L. ; Chaipinyo, K. ; Christensen, R. ; Cochrane, T. ; Rooij, M. de ; Doherty, M. ; French, H.P. ; Hickson, S. ; Hinman, R.S. ; Hopman-Rock, M. ; Hurley, M.V. ; Ingram, C. ; Knoop, J. ; Krauss, I. ; McCarthy, C. ; Messier, S.P. ; Patrick, D.L. ; Sahin, N. ; Talbot, L.A. ; Taylor, R. ; Teirlinck, C.H. ; Middelkoop, M. van ; Walker, C. ; Foster, N.E. et al. sine al.
2017, Article / Letter to editor (BMJ Open, vol. 7, iss. 12, (2017), pp. e018971)INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/donnot respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function. This will enable optimal targeting and refining the content of future exercise interventions. METHODS AND ANALYSIS: Systematic review and individual participant data meta-analyses. A previous comprehensive systematic review will be updated to identify randomised controlled trials that compare the effects of therapeutic exercise for people with knee and hip OA on pain and physical function to a non-exercise control. Lead authors of eligible trials will be invited to share individual participant data. Trial-level and participant-level characteristics (for baseline variables and outcomes) of included studies will be summarised. Meta-analyses will use a two-stage approach, where effect estimates are obtained for each trial and then synthesised using a random effects model (to account for heterogeneity). All analyses will be on an intention-to-treat principle and all summary meta-analysis estimates will be reported as standardised mean differences with 95% CI. ETHICS AND DISSEMINATION: Research ethical or governance approval is exempt as no new data are being collected and no identifiable participant information will be shared. Findings will be disseminated via national and international conferences, publication in peer-reviewed journals and summaries posted on websites accessed by the public and clinicians. PROSPERO REGISTRATION NUMBER: CRD42017054049.

Now showing items 1-2 of 2

Browsing by Author "Christensen, R."

Browse

All of HAN Publications