Browsing by Author "Kester, M.I."

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Olfactory and gustatory functioning and food preferences of patients with Alzheimer's disease and mild cognitive impairment compared to controls: the NUDAD project
Doorduijn, A.S. ; Schueren, M.A.E. de van der ; Rest, O. van de ; Leeuw, F.A. de ; Fieldhouse, J.L.P. ; Kester, M.I. ; Teunissen, C.E. ; Scheltens, P. ; Flier, W.M. van der ; Visser, M. ; Boesveldt, S. et al. sine al.
2020, Article / Letter to editor (Journal of Neurology, vol. 267, iss. 1, (2020), pp. 144-152)Our aim is to compare olfactory and gustatory function and food preferences of patients with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) with controls. We included 22 patients with MCI, 30 patients with AD and 40 controls and assessed olfactory threshold, odor discrimination and odor identification (Sniffin' Sticks), gustatory functioning (Taste Strips), and food preferences (Macronutrient and Taste Preference Ranking Task). Linear regression analyses were used to study associations of five cognitive domains or AD biomarkers with olfactory functioning. Groups did not differ in olfactory threshold, gustatory function and food preferences. Patients with MCI and AD scored lower on odor discrimination and identification than controls. Poorer memory, but no other cognitive domain, was associated with poorer odor discrimination and odor identification, but not with odor threshold. No associations with AD biomarkers were found. In conclusion, patients with MCI and AD have poorer odor discrimination and identification ability than controls, but similar detection thresholds. This is likely a consequence of poorer memory rather than directly caused by AD pathology.
A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
Fieldhouse, J.L.P. ; Doorduijn, A.S. ; Leeuw, F.A. de ; Verhaar, BJH ; Koene, T ; Wesselman, L.M.P. ; Schueren, M.A.E. de van der ; Visser, M. ; Rest, O. van de ; Scheltens, P. ; Kester, M.I. ; Flier, W.M. van der et al. sine al.
2020, Article / Letter to editor (Nutrients, vol. 12, iss. 3, (2020))Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer's disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer's disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition-this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia.
Associations Between Nutrient Intake and Corresponding Nutritional Biomarker Levels in Blood in a Memory Clinic Cohort: The NUDAD Project
Leeuw, F.A. de ; Rest, O. van de ; Doorduijn, A.S. ; Fieldhouse, J.L.P. ; Schueren, M.A.E. de van der ; Visser, M. ; Heuvel, E.G.H.M. van den ; Scheltens, P. ; Teunissen, C.E. ; Kester, M.I. ; Flier, W.M. van der et al. sine al.
2020, Article / Letter to editor (Journal of the American Medical Directors Association, vol. 21, iss. 10, (2020), pp. 1436-1438)
Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project
Leeuw, F.A. de ; Doorduijn, A.S. ; Fieldhouse, J.L.P. ; Rest, O. van de ; Teunissen, C.E. ; Berckel, B. van ; Barkhof, F. ; Visser, M. ; Schueren, M.A.E. de van der ; Scheltens, P. ; Kester, M.I. ; Muller, M. ; Flier, W.M. van der et al. sine al.
2020, Article / Letter to editor (Alzheimer's & Dementia, (2020))
A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
Fieldhouse, J.L.P. ; Doorduijn, A.S. ; Leeuw, F.A. de ; Verhaar, BJH ; Koene, T ; Wesselman, L.M.P. ; Schueren, M de van der ; Visser, M. ; Rest, O. van de ; Scheltens, P. ; Kester, M.I. ; Flier, W.M. van der et al. sine al.
2020, Article / Letter to editor (Nutrients, vol. 12, iss. 3, (2020))Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer's disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer's disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition-this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia.
Dietary Patterns Are Related to Clinical Characteristics in Memory Clinic Patients with Subjective Cognitive Decline: The SCIENCe Project.
Wesselman, L.M.P. ; Doorduijn, A.S. ; Leeuw, F.A. de ; Verfaillie, S.C.J. ; Leeuwenstijn-Koopman, M. van ; Slot, R.E.R. ; Kester, M.I. ; Prins, N.D. ; Rest, O. van de ; Schueren, M.A.E. de van der ; Scheltens, P. ; Sikkes, S.A.M. ; Flier, W.M. van der et al. sine al.
2019, Article / Letter to editor (Nutrients, vol. 11, iss. 11, (2019))
Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project.
Doorduijn, A.S. ; Visser, M. ; Rest, O. van de ; Kester, M.I. ; Leeuw, F.A. de ; Boesveldt, S. ; Fieldhouse, J.L.P. ; Heuvel, E.G.H.M. van den ; Teunissen, C.E. ; Scheltens, P. ; Flier, W.M. van der ; Schueren, M.A.E. de van der et al. sine al.
2019, Article / Letter to editor (Nutrients, vol. 23, iss. 11, (2019))

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