Browsing Han Publications by Author "Foster, N.E."

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How does hip osteoarthritis differ from knee osteoarthritis?
Hall, M. ; Esch, M. van der ; Hinman, R.S. ; Peat, G. ; Zwart, A. de ; Quicke, J.G. ; Runhaar, J. ; Knoop, J. ; Leeden, M van der ; Rooij, M. de ; Meulenbelt, I. ; Vliet Vlieland, T. ; Lems, W.F. ; Holden, M.A. ; Foster, N.E. ; Bennell, K.L. et al. sine al.
2022, Article / Letter to editor (Osteoarthritis and Cartilage, vol. 30, iss. 1, (2022), pp. 32-41)Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to date has focused on the knee, with results often extrapolated to the hip, and this extends to treatment recommendations in clinical guidelines. Extrapolating results from research on knee OA may limit our understanding of disease characteristics specific to hip OA, thereby constraining development and implementation of effective treatments. This review highlights differences between hip and knee OA with respect to prevalence, prognosis, epigenetics, pathophysiology, anatomical and biomechanical factors, clinical presentation, pain and non-surgical treatment recommendations and management.
Stratified care integrated with eHealth versus usual primary care physiotherapy in patients with neck and/or shoulder complaints: protocol for a cluster randomized controlled trial.
TIlburg, M.L. van ; Kloek, C.J.J. ; Pisters, M.F. ; Staal, J.B. ; Dongen, J.M. van ; Weerd, M. de ; Ostelo, R.W.J.G. ; Foster, N.E. ; Veenhof, C.
2021, Article / Letter to editor (BMC Musculoskeletal Disorders, vol. 22, iss. 1, (2021), pp. 143)BACKGROUND: Neck and shoulder complaints are common in primary care physiotherapy. These patients experience pain and disability, resulting in high societal costs due to, for example, healthcare use and work absence. Content and intensity of physiotherapy care can be matched to a patient's risk of persistent disabling pain. Mode of care delivery can be matched to the patient's suitability for blended care (integrating eHealth with physiotherapy sessions). It is hypothesized that combining these two approaches to stratified care (referred to from this point as Stratified Blended Approach) will improve the effectiveness and cost-effectiveness of physiotherapy for patients with neck and/or shoulder complaints compared to usual physiotherapy. METHODS: This paper presents the protocol of a multicenter, pragmatic, two-arm, parallel-group, cluster randomized controlled trial. A total of 92 physiotherapists will be recruited from Dutch primary care physiotherapy practices. Physiotherapy practices will be randomized to the Stratified Blended Approach arm or usual physiotherapy arm by a computer-generated random sequence table using SPSS (1:1 allocation). Number of physiotherapists (1 or > 1) will be used as a stratification variable. A total of 238 adults consulting with neck and/or shoulder complaints will be recruited to the trial by the physiotherapy practices. In the Stratified Blended Approach arm, physiotherapists will match I) the content and intensity of physiotherapy care to the patient's risk of persistent disabling pain, categorized as low, medium or high (using the Keele STarT MSK Tool) and II) the mode of care delivery to the patient's suitability and willingness to receive blended care. The control arm will receive physiotherapy as usual. Neither physiotherapists nor patients in the control arm will be informed about the Stratified Blended Approach arm. The primary outcome is region-specific pain and disability (combined score of Shoulder Pain and Disability Index & Neck Pain and Disability Scale) over 9 months. Effectiveness will be compared using linear mixed models. An economic evaluation will be performed from the societal and healthcare perspective. DISCUSSION: The trial will be the first to provide evidence on the effectiveness and cost-effectiveness of the Stratified Blended Approach compared with usual physiotherapy in patients with neck and/or shoulder complaints. TRIAL REGISTRATION: Netherlands Trial Register: NL8249 . Officially registered since 27 December 2019. Date of first enrollment: 30 September 2020. Study status: ongoing, data collection.
Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials.
Hayden, J.A. ; Wilson, M.N. ; Stewart, S. ; Cartwright, J.L. ; Smith, A.O. ; Riley, R.D. ; Tulder, M. van ; Bendix, T. ; Cecchi, F. ; Costa, L.O.P. ; Dufour, N. ; Ferreira, M.L. ; Foster, N.E. ; Gudavalli, M.R. ; Hartvigsen, J. ; Helmhout, P. ; Kool, J. ; Koumantakis, G.A. ; Kovacs, F.M. ; Kuukkanen, T. ; Long, A. ; Macedo, L.G. ; Machado, L.A.C. ; Maher, C.G. ; Mehling, W. ; Morone, G. ; Peterson, T. ; Rasmussen-Barr, E. ; Ryan, C.G. ; Sjögren, T. ; Smeets, R. ; Staal, J.B. ; Unsgaard-Tøndel, M. ; Wajswelner, H. ; Yeung, E.W. et al. sine al.
2020, Article / Letter to editor (British Journal of Sports Medicine, vol. 54, iss. 21, (2020), pp. 1277-1278)BACKGROUND: Low back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remains uncertainty about which individuals might benefit the most from exercise. METHODS: In parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison characteristics, and outcomes at short-term, moderate-term and long-term follow-up. We conducted descriptive analyses and one-stage IPD meta-analysis using multilevel mixed-effects regression of the overall treatment effect and prespecified potential treatment effect modifiers. RESULTS: We received IPD for 27 trials (3514 participants). For studies included in this analysis, compared with no treatment/usual care, exercise therapy on average reduced pain (mean effect/100 (95% CI) -10.7 (-14.1 to -7.4)), a result compatible with a clinically important 20% smallest worthwhile effect. Exercise therapy reduced functional limitations with a clinically important 23% improvement (mean effect/100 (95% CI) -10.2 (-13.2 to -7.3)) at short-term follow-up. Not having heavy physical demands at work and medication use for low back pain were potential treatment effect modifiers-these were associated with superior exercise outcomes relative to non-exercise comparisons. Lower body mass index was also associated with better outcomes in exercise compared with no treatment/usual care. This study was limited by inconsistent availability and measurement of participant characteristics. CONCLUSIONS: This study provides potentially useful information to help treat patients and design future studies of exercise interventions that are better matched to specific subgroups. PROTOCOL PUBLICATION: https://doi.org/10.1186/2046-4053-1-64.
Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol.
Holden, M.A. ; Burke, D.L. ; Runhaar, J. ; Windt, D. van Der ; Riley, R.D. ; Dziedzic, K. ; Legha, A. ; Evans, A.L. ; Abbott, J.H. ; Baker, K. ; Brown, J. ; Bennell, K.L. ; Bossen, D. ; Brosseau, L. ; Chaipinyo, K. ; Christensen, R. ; Cochrane, T. ; Rooij, M. de ; Doherty, M. ; French, H.P. ; Hickson, S. ; Hinman, R.S. ; Hopman-Rock, M. ; Hurley, M.V. ; Ingram, C. ; Knoop, J. ; Krauss, I. ; McCarthy, C. ; Messier, S.P. ; Patrick, D.L. ; Sahin, N. ; Talbot, L.A. ; Taylor, R. ; Teirlinck, C.H. ; Middelkoop, M. van ; Walker, C. ; Foster, N.E. et al. sine al.
2017, Article / Letter to editor (BMJ Open, vol. 7, iss. 12, (2017), pp. e018971)INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/donnot respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function. This will enable optimal targeting and refining the content of future exercise interventions. METHODS AND ANALYSIS: Systematic review and individual participant data meta-analyses. A previous comprehensive systematic review will be updated to identify randomised controlled trials that compare the effects of therapeutic exercise for people with knee and hip OA on pain and physical function to a non-exercise control. Lead authors of eligible trials will be invited to share individual participant data. Trial-level and participant-level characteristics (for baseline variables and outcomes) of included studies will be summarised. Meta-analyses will use a two-stage approach, where effect estimates are obtained for each trial and then synthesised using a random effects model (to account for heterogeneity). All analyses will be on an intention-to-treat principle and all summary meta-analysis estimates will be reported as standardised mean differences with 95% CI. ETHICS AND DISSEMINATION: Research ethical or governance approval is exempt as no new data are being collected and no identifiable participant information will be shared. Findings will be disseminated via national and international conferences, publication in peer-reviewed journals and summaries posted on websites accessed by the public and clinicians. PROSPERO REGISTRATION NUMBER: CRD42017054049.

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