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| Title: | Endotoxemia-induced inflammation and the effect on the human brain |
| Author(s): | ; ; ; ; ; ; ; ; ; |
| Publication year: | 2010 |
| Source: | Critical Care, vol. 2010, iss. 14, (2010), pp. R81 |
| ISSN: | 1466-609X |
| DOI: | https://doi.org/10.1186/cc9001 |
| Publication type: | Article / Letter to editor |
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Please use this identifier to cite or link to this item : https://hdl.handle.net/20.500.12470/475 
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| Lectorate : | External research institute |
| Journal title : | Critical Care |
| Volume : | vol. 2010 |
| Issue : | iss. 14 |
| Page start : | p.R81 |
| Abstract: |
Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served as controls. Cytokines (TNF-a, IL-6, IL1-RA and IL-10), cortisol, brain specific proteins (BSP), electroencephalography (EEG) and cognitive function tests (CFTs) were determined. Short-term systemic inflammation does not provoke or explain the occurrence of septic encephalopathy, but primarily results in an inflammation-mediated increase in cortisol and alertness.
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