Browsing Han Publications without organization data by Author "Pickkers, Peter"

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Prophylactic Haloperidol for Critically Ill Adults—Reply
Boogaard, Mark van den ; Slooter, A. J. C. ; Pickkers, Peter
2018, Article / Letter to editor (Jama : Journal of the American Medical Association, (2018), pp. 304)
Feasibility of Cognitive Training in Critically Ill Patients: A Pilot Study
Wassenaar, A. ; Rood, P. ; Boelen, D. ; Schoonhoven, Lisette ; Pickkers, Peter ; Boogaard, Mark van den
2018, Article / Letter to editor (American Journal of Critical Care, vol. 27, iss. 2, (2018), pp. 124-135)
Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis
Rood, P. ; Huisman - de Waal, G. ; Vermeulen, H. ; Schoonhoven, Lisette ; Pickkers, Peter ; Boogaard, Mark van den
2018, Article / Letter to editor (Australian Critical Care, vol. 31, iss. 3, (2018), pp. 180-187)
Delirium in critically ill patients : Impact on long-term quality of life and cognitive functioning
Schoonhoven, Lisette ; Achterberg, Theo van ; Evers, A.W.M. ; Hoeven, Hans van der ; Pickkers, Peter ; Boogaard, Mark van den
2012, Article / Letter to editor (Critical Care Medicine, vol. 2012, iss. 40, (2012), pp. 112-119)Prospective 18-month follow-up study to examine the impact of delirium during intensive care unit stay on long-term health-related quality of life and cognitive function in intensive care unit survivors.
Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction : Indications for different pathways governing delirium in inflamed and noninflamed patients
Hoeven, Hans van der ; Kox, M. ; Pickkers, Peter ; Quinn, K. ; Achterberg, Theo van ; Schoonhoven, Lisette ; Boogaard, Mark van den
2011, Article / Letter to editor (Critical Care, vol. 15, iss. 6, (2011), pp. R297)Delirium occurs frequently in critically ill patients and is associated with disease severity and infection. Although several pathways for delirium have been described, biomarkers associated with delirium in intensive care unit (ICU) patients is not well studied. We examined plasma biomarkers in delirious and nondelirious patients and the role of these biomarkers on long-term cognitive function.
Incidence and short-term consequences of delirium in critically ill patients : A prospective observational cohort study
Schoonhoven, Lisette ; Hoeven, Hans van der ; Achterberg, Theo van ; Pickkers, Peter ; Boogaard, Mark van den
2011, Article / Letter to editor (International Journal of Nursing Studies, vol. 49, iss. 7, (2011), pp. 775-783)Delirium is a serious and frequent psycho-organic disorder in critically ill patients. Reported incidence rates vary to a large extent and there is a paucity of data concerning delirium incidence rates for the different subgroups of intensive care unit (ICU) patients and their short-term health consequences. The delirium incidence in a mixed ICU population is high and differs importantly between ICU admission diagnoses and the subtypes of delirium. Patients with delirium had a significantly higher incidence of short-term health problems, independent from their severity of illness and this was most pronounced in the mixed subtype of delirium. Delirium is significantly associated with worse short-term outcome.
Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients
Swelm, R. van ; Hoeven, Hans van der ; Heemskerk, S. ; Pickkers, Peter ; Russel, F. ; Masereeuw, R. ; Boogaard, Mark van den
2011, Article / Letter to editor (Proteome Science, vol. 9, iss. 13, (2011))Suitable biomarkers associated with the development of delirium are still not known. Urinary proteomics has successfully been applied to identify novel biomarkers associated with various disease states, but its value has not been investigated in delirium patients. In a prospective explorative study hyperactive delirium patients after cardiac surgery were included for urinary proteomic analyses. Delirium patients were matched with non-delirium patients after cardiac surgery on age, gender, severity of illness score, LOS-ICU, Euro-score, C-reactive protein, renal function and aorta clamping time. Urine was collected within 24 hours after the onset of delirium. Matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) was applied to detect differences in the urinary proteome associated with delirium in these ICU patients. We included 10 hyperactive delirium and 10 meticulously matched non-delirium post-cardiac surgery patients. No relevant differences in the urinary excretion of proteins could be observed.
Assessment of delirium in ICU patients : A literature review
Schoonhoven, Lisette ; Pickkers, Peter ; Boogaard, Mark van den
2010, Article / Letter to editor (Netherlands Journal of Critical Care, vol. 14, iss. 1, (2010), pp. 10-15)A psycho-organic disorder such as delirium is a frequently occurring and serious disorder especially on Intensive Care units. Nowadays, more attention is paid to this problem by physicians, nurses and by researchers, but assessment of delirium in all ICU patients is still not common practice. If patients are not screened for delirium in a standard manner, once or several times a day, the delirium diagnose will be missed. In this systematic review we describe and analyse six delirium screening instruments available from the literature: the Cognitive Test for Delirium (CTD), the abbreviated CTD, Intensive Care Delirium Screening Checklist (ICDSC), Delirium Detection Score (DDS), NEECHAM confusion scale and the Confusion Assessment Method-ICU (CAM-ICU). Each assessment tool its characteristics, reliability and validity testing is briefly described. We conclude that important delirium criteria are not integrated into some screening tools (CTD and aCTD, DDS), or an important group of ICU patients cannot be tested (NEECHAM). The ICDSC and the CAM-ICU appear to represent the most feasible instruments for delirium screening in the ICU. Of these two tests, the CAM-ICU prevails because of the validated Dutch version and its reported high sensitivity and specificity.
Biomarkers in delirious patients at the critical care unit
Boogaard, Mark van den ; Hoeven, Hans van der ; Quinn, K. ; Schoonhoven, Lisette ; Pickkers, Peter ; Hoedemaekers, A.
2010, Article / Letter to editor (Intensive Care Medicine, vol. 2010, iss. 36, (2010), pp. suppl.-2 s221)Delirium occurs frequently in critically ill patients, and especially in severely ill and in infectious patients. Although several causal pathways for delirium have been described, the role of biomarkers in ICU patients is unknown. We investigated potential differences in various serum biomarkers between delirious and non-delirious ICU patients with and without an infection.
PRE-DELERIC, PREdiction of DELIRium in Icu patients : Development and validation of a pre diction model
Hoeven, Hans van der ; Schoonhoven, Lisette ; Pickkers, Peter ; Boogaard, Mark van den ; Donders, R. ; Achterberg, Theo van
2010, Article / Letter to editor (Netherlands Journal of Critical Care, vol. 2010, iss. 14, (2010), pp. suppl-1 s167)While delirium is a serious and frequent disorder in intensive care patients, a prediction model is currently not available. We developed and validated a delirium prediction model for adult intensive care patients and determined its additional value compared to the prediction of the caregivers.
Endotoxemia-induced inflammation and the effect on the human brain
Schoonhoven, Lisette ; Boogaard, Mark van den ; Hoeven, Hans van der ; Fick, I. ; Ramakers, B. ; Alfen, N. van ; Werf, S. van der ; Verbeek, M. ; Hoedemaekers, A. ; Pickkers, Peter
2010, Article / Letter to editor (Critical Care, vol. 2010, iss. 14, (2010), pp. R81)Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served as controls. Cytokines (TNF-a, IL-6, IL1-RA and IL-10), cortisol, brain specific proteins (BSP), electroencephalography (EEG) and cognitive function tests (CFTs) were determined. Short-term systemic inflammation does not provoke or explain the occurrence of septic encephalopathy, but primarily results in an inflammation-mediated increase in cortisol and alertness.
De geagiteerde patiënt op de Intensive Care
Pickkers, Peter ; Boogaard, Mark van den ; Schoonhoven, Lisette
2009, Part of book or chapter of book (, pp. 197-203)Intensive care-geneeskunde maakt de laatste jaren een stormachtige ontwikkeling door. Steeds meer mensen komen er in hun dagelijkse werk mee in aanraking en daardoor ontstaat er een groeiende behoefte aan literatuur over dit onderwerp. Technische, maar met name ook praktijkgerichte literatuur. Venticare geeft onder de naam Capita Selecta ieder jaar een interessante verzameling artikelen uit op het gebied van de intensive care-geneeskunde. Alle artikelen zijn geschreven door deskundigen uit het vakgebied. De nadruk ligt op de praktische toepasbaarheid van de beschreven stof.
Implementation of a delirium assessment tool in the ICU can influence haloperidol use
Mintjes, Joke ; Hoeven, Hans van der ; Pickkers, Peter ; Roodbol, Petrie ; Schoonhoven, Lisette ; Achterberg, Theo van ; Boogaard, Mark van den
2009, Article / Letter to editor (Netherlands Journal of Critical Care, vol. 13, iss. 4, (2009), pp. R131)In critically ill patients, delirium is a serious and frequent disorder that is associated with a prolonged intensive care and hospital stay and an increased morbidity and mortality. Without the use of a delirium screening instrument, delirium is often missed by ICU nurses and physicians. The effects of implementation of a screening method on haloperidol use is not known. The purpose of this study was to evaluate the implementation of the confusion assessment method-ICU (CAM-ICU) and the effect of its use on frequency and duration of haloperidol use.

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