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Browsing Han Publications without organization data by Author "Schaafsma, Gertjan"
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Lactic acid and Lactates in Health and wellness 2010, Article / Letter to editor (Nutrafoods, vol. 9, iss. 1, (2010), pp. 7-16)This review aims to integrate the present state of knowledge on lactate metabolism in human and mammalian physiology as far as it could be subject to nutritional interventions. An integrated view on the nutritional, metabolic and physiological aspects of lactic acid and lactates might open a perspective for innovative nutritional applications of lactates in health and wellness. Lactic acid was classically considered to be a dead end waste product of anaerobic glycolysis during severe exercise. Mammals, however, do not excrete lactate indicating that lactate cannot be considered as a dead metabolic end product. Despite a rapid and massive production of lactate, lactate is finally oxidized to the normal metabolic end products CO2 and H2O. Besides direct metabolic effects, nutritional applications of lactic acid and lactates are also considered in relation to dietary mineral supply. To the background that lactic acid is in fact a semi manufactured metabolic product, various nutritional applications are proposed in relation to metabolic training of athletes, modulation of metabolic rate, appetite control and excretion of faecal fat for weight management, lowering the glycemic index of bread and improved mineral supplementation in nutritional formulas for infants and people using proton inhibitors. -
Health benefits of milk beyond traditional nutrition 2009, Article / Letter to editor (Australian Journal of Dairy Technology, vol. 64, iss. 1, (2009), pp. 113-116)This paper provides an overview of health benefits of consumption of milk which are not easily explained by traditional nutritional knowledge. -
Fish consumption and markers of colorectal cancer risk : A multicenter randomized controlled trial 2009, Article / Letter to editor (The American Journal of Clinical Nutrition, vol. 90, iss. 2, (2009), pp. 354-361)Diet is a major factor in the etiology of colorectal cancer, with high fish consumption possibly decreasing colorectal cancer risk, as was shown in several observational studies. To date, no intervention trials have examined the possible beneficial effects of fish intake on colorectal cancer risk. The objective was to investigate the effects of a 6-mo intervention with oil-rich or lean fish on apoptosis and mitosis within the colonic crypt. In a multicenter, randomized, controlled intervention trial, patients with colorectal polyps, inactive ulcerative colitis, or no macroscopic signs of disease were recruited (n = 242) and randomly allocated to receive dietary advice plus either 300 g oil-rich fish (salmon) per week (n = 82), 300 g lean fish (cod) per week (n = 78), or only dietary advice (DA) (n = 82). Apoptosis and mitosis were measured in colonic biopsy samples collected before and after intervention (n = 213). The total number of apoptotic cells per crypt did not increase in the salmon or cod group: -0.10 (95% CI: -0.36, 0.16) and -0.06 (95% CI: -0.32, 0.20), respectively, compared with the DA group. The total number of mitotic cells per crypt decreased nonsignificantly in the salmon group (-0.87; 95% CI: -2.41, 0.68) and in the cod group (-1.04; 95% CI: -2.62, 0.53) compared with the DA group. Furthermore, the distribution of mitosis within the crypt did not significantly change in either group. An increase in the consumption of either oil-rich or lean fish to 2 portions weekly over 6 mo does not markedly change apoptotic and mitotic rates in the colonic mucosa. This trial was registered at www.clinicaltrials.gov as NCT00145015.
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Is pure voeding beter dan bewerkte? 2009, Article / Letter to editor (Nederlands Tijdschrift voor Voeding & Diëtetiek, vol. 64, iss. 5, (2009), pp. 26-27)Door allerlei technische ontwikkelingen zijn onze oorspronkelijke voedingsmiddelen veranderd. Vlees, vis, groenten, fruit, noten en zaden zijn verdrongen door bewerkte en voorverpakte producten, light producten en functionele voedingsmiddelen. Is dit een vooruitgang of is het gezonder om pure, onbewerkte producten te eten?
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Naar een toereikende inname van vitamine D : Een advies van de Gezondheidsraad 2009, Article / Letter to editor (Huisarts en Wetenschap, vol. 2009, iss. 2, (2009), pp. 73-75)De Gezondheidsraad adviseert de minister van VWS om de voorlichting over het belang van extra vitamine D eenduidig te maken teneinde de inname ervan te stimuleren. Vitamine-D-tekort komt voor bij mensen met een donkere huidskleur, bij mensen die onvoldoende buiten komen, bij vrouwen die een sluier dragen, zwanger zijn of borstvoeding geven, en bij ouderen. Het hoogste risico hebben bewoners van verpleeg- en verzorgingshuizen, alsook jonge kinderen die geen vitamine-D-supplement of flesvoeding krijgen. Deze risicogroepen hebben dagelijks 10 of 20 microgram extra vitamine D nodig. Daarbij moet ook de calciuminname voldoende zijn.
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Toward an optimal use of folic acid : An advisory report of the Health Council of the Netherlands 2009, Article / Letter to editor (The American Journal of Clinical Nutrition, vol. 63, iss. 8, (2009), pp. 1034-1036)In this report, benefits (preventing neural tube defects and folate deficiency), risks (masking vitamin B(12) deficiency), and uncertain effects (risk of colon cancer) of folic acid supplementation and fortification have been weighted. On the basis of the available evidence, the Health Council of the Netherlands advises the Dutch government to improve the use of folic acid approximately at the time of conception by increased education and the implementation of preconception care. It further recommends considering fortifying staple foods, provided that voluntary fortification of specific foods is banned, as otherwise children are at risk of having an excessively high intake of folic acid. Policy making in relation to fortification should take into account all possible health effects, even if the evidence is not strong
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Safety of protein hydrolysates, fractions thereof and bioactive peptides in human nutrition 2009, Article / Letter to editor (European Journal of Clinical Nutrition, vol. 63, (2009), pp. 1161-1168)This paper evaluates the safety for humans with regard to consumption of protein hydrolysates and fractions thereof, including bioactive peptides. The available literature on the safety of protein, protein hydrolysates, fractions thereof and free amino acids on relevant food legislation is reviewed and evaluated. A new concept for the safety assessment of protein hydrolysates and fractions thereof is developed. Benchmarks for the evaluation are safety of total protein intake, safety of free amino acid intake, documented history of safe use, outcome of questionnaires in efficacy studies and safety studies.
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Lactose and lactose derivatives as bioactive ingredients in human nutrition 2008, Article / Letter to editor (International Dairy Journal, vol. 18, iss. 5, (2008), pp. 458-465)Lactose is a unique disaccharide, which occurs exclusively in the milk of mammals. It has wide applications as a food ingredient and in pharmaceutical preparations. Discouragement of milk consumption, because of the existence of lactase deficiency in the majority of the world population, is unjustified, because even in the complete absence of this enzyme, nutritionally significant volumes of milk, corresponding to about 11 g of lactose per day, are well tolerated, if the milk intake is distributed over the day and combined with meals.
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Sulfur in human nutrition - effects beyond protein synthesis 2008, Article / Letter to editor (Nutrafoods, vol. 7, iss. 4, (2008), pp. 5-10)That sulfur is essential to humans is based on the requirement of S-animo acids for normal growth and maintenance of nitrogen balance and not on the optimization of metabolic proccesses involving the synthesis of non-protein sulphur containing compounds. This paper reviews the significance of sulfur in the diet with respect to its role beyond protein synthesis.
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Waarom overdaad schaadt en rust roest 2008, Inaugural lecture Intreerede uitgesproken bij het aanvaarden van het ambt van Lector 'Sport, Voeding en Leefstijl' aan de Faculteit Gezondheid, Gedrag en Maatschappij van de Hogeschool van Arnhem en Nijmegen op 19 juni 2008
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The role of nutrition in joint health promotion 2007, Article / Letter to editor (Nutrafoods, vol. 6, iss. 3, (2007), pp. 5-11)Many people experience with advancing age complaints caused by degenerative changes of the cartilage in their joints, often leading to osteoarthritis (OA). Prevention and/or reduction of OA may include stimulation of the formation of new cartilage, the reduction of degenerative changes and the treatment of symptoms (pain, stiffness). On the basis of this review, it is concluded that the best opportunities for the nutritional prevention and/or treatment of OA are in the reduction of inflammation and not in the stimulation of new cartilage formation.
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Health issues of whey proteins: 3. gut health promotion 2007, Article / Letter to editor (Current Topics in Nutraceutical Research, vol. 5, iss. 1, (2007), pp. 29-34)This paper reviews the potential of whey protein to promote gut health. The high digestibility and specific amino acid composition of whey protein, as present in whey powder, whey protein concentrate and whey protein isolate, explain why ingestion of whey protein will exert this beneficial effect.
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